"Crystal Phoenix"

"Gryphon" Modular Microdispenser System

– "Crystal Gryphon"
– "Gryphon LCP"
– "Crystal Gryphon LCP"

“Gryphon” general features:

• No disposables, cutting operating costs
• The “All-In-One” Microdispenser enables screen and protein drop-setting in one protocol
• Modular design allows for custom set-ups
• Versatile and upgradeable
• Add a nano or LCP dispenser at any point in the future
• Set up sitting and hanging drop vapour diffusion crystallization experiments
• Set up batch crystallization drops (under oil)
• Combines individual precipitant and protein solutions into crystallization trial wells
• X-Y stage with two plate positions and one wash station
• Low maintenance

96 Syringe Head*:

“Scorpion” high-speed single channel pipettor / screen builder

• Extremely versatile work station can perform anything that can be done with hand-held pipettors, but with the speed, reliability and precision of an automated dispenser
• High displacement speed gives the opportunity to perform a variety of different liquid handling applications including genomic methods such as PCRs
• NEW! Nucleic acid normalization as new application for the system with optimized step-by-step software
• 3 dispense modes: Forward Mode, Sequential Mode, Reverse Mode
• Compatible with 20 µl, 50 µl, 200 µl and 1000 µl pipette tips with dispensing down to approx. 1 µl
• Multiple tip sizes can be used in one protocol
• Suitable pipette tips
• Liquid transfers can be defined as volume, concentration or pH
• Possibility to set up multiple plates with varying pH, different additives and varying concentration e. g normalization of salt screens
• The deck has 6 SBS-format plate positions and can accommodate 96 racked 15 ml tubes, deep well blocks, standard 24, 96, 384 and 1536-well plates as well as 96 and 24 well protein crystallization plates, and tip racks
• Pipette head is designed to reach the bottom of tall tubes such as 15 ml and 50 ml tubes, as well as deep well blocks
• Re-array screens from 15 ml tubes into 96-well plates
• Large database of screening reagents contains all standard commercial screens
• Set up 24-well protein crystallization plates with an optimized screen, and dispense the protein
• Movement velocity of 2 meters / sec. with extreme accuracy
• Intelligent motion control software optimizes dispense paths and volumes
• Liquid level sensing allows the tip to follow liquid levels improving aspirate and dispense accuracies
• Intuitive software allows for the easy design of n-dimension grids and assays
• Easy set-up of user-defined and gradient screen plates using an innovative graphic software
• Software graphically shows the content of each well
• Possibility to import / export csv-files facilitates data transfer and the creation of custom screens
• Positive air displacement pipette head and a vast reagent database with pre-defined settings make it easy to work with a wide range of fluid viscosities, such as 50 % PEG 20,000, 80 % Glycerol and DMSO
• Environment: 4 °C to 70 °C, non condensing
• Dimensions: (w x h x d) 48.3 cm x 69.8 cm x 48.3 cm
• Cat.-No.: 640-1000-10 with desktop computer and multiple software licenses

Pipette Tips

Pipette tips for the Scorpion for 50 µl, 200 µl and 1000 µl volume options.
Tips are available sterile, non-sterile, with or without filter.

Cat. No. Description
640-1300-00  1000 µl Pipette Tips, 1536/case
640-1300-01  ∅200 µl Pipette Tips, 2304/case
640-1300-02  0050 µl Pipette Tips, 2304/case

640-1301-00  1000 µl Pipette Tips with Filter, 1536/case, steril
640-1301-01 0∅200 µl Pipette Tips with Filter, 2304/case, steril

Spring Plate for Low Volume Optimization

Set up complete optimization plates on the Scorpion with the spring fixture. Ideal for setting up the Intelli-Pate 24-4 (Cat. No.: 102-0004-00) as scale-up optimization plate.

Cat. No. Description
640-1206-01   Scorpion Low Volume Dispense Platform

Plate Adapter

Set up optimization directly into a Linbro plate with the Scorpion Linbro Plate Adapter.

Cat. No. Description
640-1205-01 Scorpion Linbro Plate Pdapter

Racks

Each rack is magnetically keyed to the Scorpion deck to ensure proper alignment.

Cat. No. Description
640-1099-01  Tube Rack Inserts for 1,5 ml and 2,0 ml tubes
640-1200-01  15 ml Tube Rack (for up to 24 x 15 ml tubes)
640-1200-02  50 ml Tube Rack (for up to 8 x 50 ml tubes)
640-1201-01  Pipette Tip Rack

Further racks availible. Please contact us.

"CrysCam™"

Digital Microscope for Protein Crystal Observation and Documentation

The CrysCam™ Digital Microscope allows you to capture the images of an entire plate with a click of the mouse. The stage and easy-to-use software automatically capture the image of each well and then moves to the next. With the small footprint, the device fits into a small space and can also be set up in a cold room. The CrysCam™ can be used to see crystals during crystallization, instead of looking through a microscope. The high resolution and precise X-Y stage easily mounts to the CrysCam™ base.

CrysCam™ features

• Compatible with 96-well, 24-well Linbro and Terasaki plates (adapters available)
• Reads a 96-well plate in less than three minutes
• Can be used in a cold room at 4 °C
• Quality par focal zoom lens with iris
• Integrated cross polarization
• 6.5 x zoom with 3.87 mm x 5.16 mm - 0.6 mm x 0.8 mm field of view
• 3 Mpix CMOS, 8.38 mm sensor USB cameras
• Modular and upgradeable components
• Smooth large base platform with integrated LED lighting
• Image acquisition and processing software
• Easy-to-use Windows software (Windows.NET)
• Integrated scoring database for analysis of score in the software
• Accurate and precise closed-loop control system
• Predefined plate library makes choosing the right well location quick and easy/li>
• Stage resolution down to 0.0033 mm
• Size: (w x h x d) 44.45 cm x 33.02 cm x 34.29 cm, 10.66 kg
• Users can upgrade their system to a CrysCamplus

"CrysCamplus"

Digital Microscope for Protein Crystal Observation and Documentation

"CrysCamplus" features:

• Modular customized configurations
• Available with 1 or 2 objectives: 5 x, 10 x, 15 x
• View both visual and UV-images for any well side-by-side
• Monochromatic 6 Mpix camera
• Compatible with polarization and fluorophores such as CY3 and GFP
• Score and compare wells of interest
• Compatible with all SBS format plates, LCP slides, Linbro, and VDX plates
• Can be placed in a cold room
• Any existing CrysCam™ can be upgraded to a CrysCamplus
• The software makes it quick and easy to compare UV and visible images or sets of images taken on different days
• The magnification and position of the well in each viewing window can be synchronized for easy comparison
• Multi-seat software licenses allow all users to view images from any computer

"CrysCamUV™" (and plate incubators)

Protein crystallization imaging system with UV and visible light and options for working with fluorophores

• Automatically scan the plate and capture visual and UV images and save for review at any time
• Scan multiple wells in one run, possible to scan sub-wells
• View both visual and UV image for any well side-by-side
• Capture images with two different wavelengths in the UV-spectrum: 334 nm and 365 nm
• Create a workflow and image several light sources in one protocol e. g. visible light, UV-light, Texas Red and cross-polarization
• The CrysCamUV™ can be used to capture crystal images in nano size drops
• Ability to capture multiple slices and create a highly detailed image of the complete drop
• Powered focus and zoom through the software control
• Score and compare wells of interest
• Software offers integrated database for analysis and score
• Parfocal lens remains focused when zooming
• Artemis VS60 camera with a resolution of 2750 x 2205 (6.0 MPix)
• Digital image of 2.37 microns/pixel with a minimum zoom to 0.7 microns/pixel
• Can flag wells of interest
• Can view individual wells and sub-wells with or without a polarizer
• Compatible with all plates in SBS-sized format and Linbro plates
• Determine crystal X-Y-Z position for use with in-situ crystal diffraction
• Filter removes UV reflections from plates
• Integrated cooling function can set temperature for the camera down to -10 °C to get better images
• Enclosure covers lens and plates to block stray light
• Customized filter options for working with fluorophores available e. g. Texas Red
• Optional cooling version to keep plates that have been stored in the refrigerator cool while imaging
• Plate hotels for 42, 210 and 504 plates available

Refurbished "Hydras"

Art Robbins Instruments continues to offer the entire product line of "Refurbished Hydras" to offer you high-speed aspiration and dispension of certain volumes at a low price. The "refurbished Hydras" are overhauled, inspected, assembled, tested and tested by the same engineering team that originally designed and manufactured these devices. All syringes are revised and brought in mint condition. For all "refurbished devices" the warranty is one year.

"Refurbished Hydras" features:

• 384 or 96 syringes
• Equipped with or without washing module
• Equipped with or without plate positioner
• Syringe size of 100 μl, 290 μl, 580 μl or 1 ml
• Syringes made of flexible Nitinol or PTFE-coated steel

LCP Mixing Station

The LCP (lipidic cubic phase) Mixing Station is ideally suited for the mixing of viscous solutions often used for the crystallization of membrane proteins.

Features:

• Suitable for various types of syringes such as from Hamilton or Art Robbins Instruments
• >Each volume can be mixed as long as both syringes have the same loading volume
• Prevents variations over several days or those that can occur by different users
• Last mixing time is shown on the display
• Easy and fast to load
• By loading the syringe, the mixing parameters are automatically adjusted so that the volume to be mixed corresponds to the sample volume in the syringe
• Acoustic alarm signal can be set automatically after entering the time
• Easy to clean mixing chamber made of stainless steel
• Compact size (w x h x d): 34.3 cm x 13.9 cm x 11.4 cm
• Choice of syringes available

LCP Hand-Held Multi Volume Dispenser

The LCP Hand-Held Dispenser can be used with syringes from different manufacturers such as Art Robbins Instruments or Hamilton.

The Hand-Held Dispenser allows setting up to 200 steps and can move 1, 2 or 3 steps per click. The volume of the syringe can be divided into 50, 100 or 200 steps per dispense, e. g. for 10 µl the dispense volume can be set to 50 nl, 100 nl or 200 nl.

LCP Mixer/Dispenser - Starter Kit

Parts included in the starter kit:

• 1 x LCP Mixing Station
• 1 x LCP Hand-Held Multi Volume Dispenser
• 1 x 10 µl Syringe plus 3 x Needles
• 2 x 100 µl Syringe
• 1 x LCP Coupling and Ferrule Mix, ARI-ARI syringe
• 1 x LCP Coupling and Ferrule Mix, ARI-Hamilton syringe

Hood and Trolley for Robotic Systems

• Panels and doors manufactured in clear plastic
• Aluminium frame
• Opening with rubber cover Ø 80 mm (right) for cables
• Front with door and extra reach-through opening
• Suitable for all robotic systems which require a constant humidity (see below for measurements)
• Hood suitable for Single-channel Phoenix and all modular Gryphon robots from Art Robbins Instruments

Inclusive:

• Ultra-sonic humidifier
• Humidity controller
• Humidity sensor

Optional: 

• Trolley: 4 locking castors, base plate and 2 shelves
• Slight design changes possible

"Scorpion"  for Chemistry

Applications:

• High-Throughput Experimentation
• Reaction optimization
• Reaction miniaturization to screen conditions without wasting precious samples
• Long term scheduled reaction sampling for kinetic assays
• High-Throughput screening of ligands or substrates for reactions
• Preparation of LC-MS samples

Features:

"Phoenix" for the Chemical Research Laboratory

Fields of application:

• Biofuel research
• Bacterial metabolic engineering
• Biocatalyst development
• Enzyme optimization

Features:

• No disposables, cutting operating costs
• Ideal dispensing system to work with organic solvents such as Methyl Isobutyl Ketone (MIBK) and Butyl Acetate
• Glass, stainless steel and a fluoropolymer are the only wettable surfaces
• 96 head compatible with all commonly used chemicals
• Chemically resistant deck
• Capacity for six blocks and/or tube racks plus three wash positions
• Compact size allows to place the system in a fume hood
• Closed-loop motion control on each axis: verification of task completion via encoders on each motor
• Integrated wash-system with computer controlled peristaltic pumps and wash reservoirs
• Windows-based drag-and-drop software
• Choice of 96-head with 1 ml TCSS, widebore TCSS, or flexible needles (please contact us for more information)
• Dispense head can be exchanged easily within minutes for servicing
• Dispense volumes down to 1 µl with a CV < 5 %

"Cobra" - 1- or 4-Channel Nano Dispenser

• Ideal for preparation of PCR Master Mixes, biochemical assays and drug development
• Low dead volume minimizes waste
• Fast non-contact dispensing into 96-, 384- and even   1536-well plates, deep well blocks and PCR plates
• Suitable for dispensing cells into Terasaki plates (only 1-Channel Cobra)
• Can be used for "Crossmatching" in HLA-laboratories and hospitals
• Holds full-skirt and semi-skirted PCR plate adapters
• Dispense 300 nl to 5 ml using 1 or 4 non-contact nano-dispensers
• Dispense any volume, any well with up to 4 independent reagents in the same pass
• Dispense gradients for direct dilutions
• Easy-to-use, computer controlled and Windows based software
• Mixed modes in one run are possible (switch between aspirate/dispense and bulk dispense)
• Aspirate from deep well blocks, 0.2 ml and 1 ml or 2 ml tubes
• 2 position plate deck
• Liquid level sensing for all reagent bottles
• Can be integrated into automatic systems for storage of plates --> please ask for further information
• Integrated wash system

Automatic Typing Tray Oiler for HLA laboratories

AutoScope

Customized product to score Terasaki plates on Microscopes

"AutoScope” features:

• Secure handling of Terasaki plates on different microscopes.

Single and multiple (six and eight) hand-held Syringe Dispensers

• Designed to simplify the multiple liquid handling steps in serological tests
• Single, six and eight precision glass syringes in a hand-held, push button repeating dispensing mechanism
• Less than 1 % variation between the single syringes
• Syringe plungers with PTFE tips. Replacement syringes and plungers are available
• Syringe volumes from 25 µl to 500 µl
• Graduated to deliver 1/50 of the total volume
• All hand-held dispensers are also available with shooting needle

Tissue typing single Microsyringes and Repeating Dispensers

• Coated stainless steel syringes (fixed, inflexible)
• „Soft-drop“, wide syringes, hanging drops by dispensing
• „Shooting“, narrow syringes, drop-dispensing by pressure
• 50 step repeating dispenser

Cell Microsyringes and Repeating Dispensers

• 80 step repeating dispenser
• For filling 60-well or 72-well Terasaki plates

Stream Splitter

• For 36-, 60-, 72- and 96-well plates
• Among other things suitable for oil, eosin or formalin
• Four dispenser heads available: 6, 8, 10 or 12 needles
• Suitable fittings for connection to the dispenser
• Autoclavable

“Complement Cooling System” and accessories

• Cooling system for 6 x 10 ml complement trays
• For work without ice bath
• Reusable cooling block with refreezable coolant
• Keeps a temperature of less than 5 ° C for over an hour